It's 1947 Hollywood and Eddie Valiant (Bob Hoskins), a down-on-his-luck detective is hired to find proof that Marvin Acme, gag factory mogul and owner of Toontown, is playing hanky-panky with femme fatale Jessica Rabbit, wife of Maroon Cartoon superstar, Roger Rabbit. When Acme is found murdered, all fingers point to Roger, who begs the Toon-hating Valiant to find the real evildoer.